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Target intelligence / Profile preview
Sodium Channel Protein (NaCh)
- Target
- NaCh
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Sodium channel proteins are integral membrane proteins that form ion channels, specifically conducting sodium ions (Na⁺) through the cell membrane. They play a critical role in generating and propagating action potentials in excitable cells such as neurons, muscle cells, and cardiomyocytes. The most well-studied class is the voltage-gated sodium channel (VGSC), which opens in response to changes in membrane potential. They are targets for various drugs, and mutations can lead to sodium channelopathies.
- Other names
- Voltage-gated sodium channelVGSCSodium channel
02
Mechanism of action
Blockade of sodium channels, modulation of gating properties
03
Biological functions
Action potential generationNerve impulse transmissionExcitation-contraction couplingElectrical signaling
04
Disease associations
EpilepsyCardiac arrhythmiaChronic painSodium channelopathy
05
Safety considerations
Cardiac toxicityNeurological side effectsArrhythmias
06
Interacting drugs
Local anesthetics
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