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Target intelligence / Profile preview
Sodium Channel Protein (Nociceptive Subtype)
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
Voltage-gated sodium channels (VGSCs), specifically Nav1.7, Nav1.8, and Nav1.9, are essential for pain signaling in nociceptors. They contribute to action potential generation and modulation of neuronal excitability. Mutations can cause altered pain sensitivity, and they are major targets for novel analgesics. These channels are dynamically regulated following nerve injury or inflammation and upregulation can contribute to hyperexcitability seen in chronic pain states.
- Other names
- Nav1.7Nav1.8Nav1.9SCN9ASCN10ASCN11AVoltage-gated sodium channel (nociceptive subtype)
02
Mechanism of action
Block voltage-gated sodium channels, preventing sodium influx and action potential generation/propagation.
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitability modulationPain signaling
04
Disease associations
PainChronic painInflammationNeuropathic painCongenital insensitivity to pain
05
Safety considerations
Potential for affecting normal sensation or motor function with non-selective blockersCardiac effects
06
Interacting drugs
Lidocaine
4 more in the full profile.
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