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Target intelligence / Profile preview
Sodium channel protein epithelial subunit alpha (SCNN1A)
- Target
- SCNN1A
- Molecular classification
- Ion channel, Sodium channel, Epithelial sodium channel (ENaC) subunit
01
Overview
The sodium channel protein epithelial subunit alpha, encoded by the SCNN1A gene, is one of the three essential pore-forming subunits (alpha, beta, gamma) that make up the epithelial sodium channel (ENaC). ENaC is a non-voltage-gated, amiloride-sensitive ion channel located on the apical surface of epithelial cells in various tissues such as kidney, lung, colon, and sweat glands. The primary function of ENaC is to mediate sodium reabsorption across high-resistance epithelia and thus regulate body salt and water homeostasis.
- Other names
- BESC2ENaCaENaCalphaSCNEASCNN1
02
Mechanism of action
Amiloride blocks Na+ entry through ENaC channels.
03
Biological functions
Sodium ion transportRegulation of extracellular fluid osmolarityBlood pressure regulationElectrolyte balance
04
Disease associations
Autosomal recessive pseudohypoaldosteronism type 1BLiddle syndromeHypertensionPulmonary edemaCystic fibrosis
05
Safety considerations
Overactivity contributes to hypertensionImpaired function may contribute to pulmonary edema or cystic fibrosis
06
Interacting drugs
Amiloride
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