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Target intelligence / Profile preview
Voltage-gated sodium channel protein type 2 subunit alpha (Nav1.2)
- Target
- Nav1.2
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Voltage-gated sodium channel protein type 2 subunit alpha (Nav1.2) is a transmembrane protein crucial for generating and propagating action potentials in neurons. Encoded by the SCN2A gene, it facilitates the selective passage of Na+ ions across cell membranes in response to voltage changes. Mutations in SCN2A are associated with various neurological disorders, including epilepsy and autism spectrum disorder, highlighting its critical role in neurodevelopment and neuronal function.
- Other names
- SCN2ASodium channel protein type 2 subunit alpha
02
Mechanism of action
Blockage of sodium channel, preventing Na+ influx and inhibiting action potential propagation.
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitability
04
Disease associations
EpilepsyAutism spectrum disorderInfantile spasmsBipolar disorder
05
Safety considerations
Cardiac arrhythmiaSeizuresNeurotoxicity
06
Interacting drugs
Tetrodotoxin
1 more in the full profile.
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