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Sodium channel protein type 3 subunit alpha
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
The sodium channel protein type 3 subunit alpha (Nav1.3), encoded by the SCN3A gene, is a pore-forming subunit of the voltage-gated sodium channel. It mediates the depolarizing phase of action potentials in excitable membranes. Mutations or dysfunctions are associated with various neurological conditions including epilepsy.
- Other names
- Nav1.3SCN3A
02
Mechanism of action
Voltage-gated sodium channel blockade
03
Biological functions
Membrane depolarizationAction potential generationNeuronal excitability
04
Disease associations
EpilepsyNeurodevelopmental disorders
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