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Target intelligence / Profile preview
Sodium channel protein type 5 subunit alpha (NaV1.5)
- Target
- NaV1.5
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
Sodium channel protein type 5 subunit alpha (NaV1.5) is the pore-forming α-subunit of the voltage-gated sodium channel predominantly expressed in cardiac muscle cells. It mediates the rapid influx of sodium ions (Na+) during phase 0 of the cardiac action potential, which is responsible for the fast depolarization and propagation of electrical impulses throughout heart tissue. Mutations in SCN5A are associated with several inherited arrhythmia syndromes.
- Other names
- hH1Sodium channel protein cardiac muscle subunit alphaVoltage-gated sodium channel subunit alpha Nav1.5Sodium channel protein type V subunit alphaVoltage-gated sodium channel type V α-subunitType 5 voltage-gated sodium channel
02
Mechanism of action
Directly blocks NaV1.5 activity
03
Biological functions
Mediates rapid influx of sodium ions (Na+) during phase 0 of the cardiac action potentialFast depolarization and propagation of electrical impulses throughout heart tissueInitiating and coordinating each heartbeatMaintaining normal heart rhythmFormation of infranodal ventricular conduction system
04
Disease associations
Romano-Ward syndrome / Long QT syndromeBrugada syndromeSick sinus syndromeAtrial fibrillationDilated cardiomyopathy
05
Safety considerations
Pro-arrhythmic risksUnderlying genetic background influences drug response
06
Interacting drugs
Class I antiarrhythmic drugs
07
Biomarkers
Pathogenic SCN5A variants
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