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Target intelligence / Profile preview
Sodium channel protein type 6 subunit alpha (NaV1.6)
- Target
- NaV1.6
- Molecular classification
- Ion channel, Voltage-gated sodium channel
01
Overview
NaV1.6 is a voltage-gated sodium channel primarily responsible for the initiation and propagation of action potentials in neurons, especially within the central nervous system. It is encoded by the SCN8A gene and plays a critical role in high-frequency neuronal firing due to its unique biophysical properties such as persistent and resurgent currents. Its structure-function relationships make it both fundamental physiologically and highly relevant clinically as a drug target for neurological disorders like epilepsy.
- Other names
- SCN8A
02
Mechanism of action
Modulation of neuronal excitability by affecting sodium ion flow.
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitabilitySodium ion transport
04
Disease associations
EpilepsyNeurological disorders
05
Safety considerations
Potential for off-target effects on other sodium channel subtypesRisk of altered cardiac or neuronal function due to changes in sodium channel activity
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