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Target intelligence / Profile preview
Sodium Channel Protein Type 7 Subunit Alpha (Nav1.7)
- Target
- Nav1.7
- Molecular classification
- Voltage-gated sodium channel, Ion channel
01
Overview
Nav1.7, also known as sodium channel protein type 7 subunit alpha, is a voltage-gated sodium channel primarily expressed in peripheral neurons, especially at the endings of pain-sensing nerves called nociceptors. It is encoded by the SCN9A gene and plays a critical role in generating and conducting action potentials in excitable cells, particularly sensory neurons involved in pain perception. Mutations in SCN9A can cause severe pain syndromes or congenital insensitivity to pain, making Nav1.7 a target for analgesic drug development.
- Other names
- SCN9A
02
Mechanism of action
Blockade of sodium ion conductance through the Nav1.7 channel pore.
03
Biological functions
Action potential generationPain signal transmissionSetting neuronal firing thresholdAmplification of membrane depolarizations
04
Disease associations
Inherited erythromelalgiaParoxysmal extreme pain disorderCongenital insensitivity to painNeuropathic pain
05
Interacting drugs
Tetrodotoxin
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