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Target intelligence / Profile preview
Sodium channel protein type 8 subunit alpha (Nav1.6)
- Target
- Nav1.6
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Sodium channel protein type 8 subunit alpha (Nav1.6) is the pore-forming alpha subunit of a voltage-gated sodium channel complex, encoded by the SCN8A gene. It is essential for initiating and propagating action potentials in neurons, especially at nodes of Ranvier where it enables rapid saltatory conduction. Mutations in SCN8A are associated with severe neurological disorders, particularly epileptic encephalopathy, characterized by early-onset seizures and intellectual disability due to altered channel gating properties.
- Other names
- SCN8ACERIIICIATEIEE13MEDNaCh6PN4sodium voltage-gated channel alpha subunit 8BFIS5MYOCL2DEE13
02
Mechanism of action
Voltage-gated sodium channel blockade/modulation
03
Biological functions
Action potential generationNeuronal excitabilitySodium ion transmembrane transportSaltatory conduction
04
Disease associations
Epileptic encephalopathyEarly infantile epileptic encephalopathySeizuresIntellectual disability
05
Safety considerations
Potential for off-target effects on other sodium channelsRisk of cardiac arrhythmias
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