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Target intelligence / Profile preview
Sodium channel protein type 9 subunit alpha (Nav1.7), Sodium channel protein type 10 subunit alpha (Nav1.8), and Sodium channel protein type 11 subunit alpha (Nav1.9) (Nav1.7/Nav1.8/Nav1.9)
- Target
- Nav1.7/Nav1.8/Nav1.9
01
Overview
Voltage-gated sodium channels Nav1.7, Nav1.8, and Nav1.9 (encoded by SCN9A, SCN10A, and SCN11A, respectively) are essential mediators of pain signaling in the peripheral nervous system [1, 4]. These channels are}
- Other names
- SCN9ASCN10ASCN11ANav1.7Nav1.8Nav1.9Peripheral voltage-gated sodium channelsPN1PN3NaN
02
Biological functions
Action potential generationAction potential propagationNociceptionSensory transductionElectrogenesisRegulation of resting membrane potential
03
Biomarkers
SCN9A gene mutationsSCN10A gene mutationsSCN11A gene mutationsIntraepidermal nerve fiber density (IENFD)
Beyond the preview
Go deeper on Sodium channel protein type 9 subunit alpha (Nav1.7), Sodium channel protein type 10 subunit alpha (Nav1.8), and Sodium channel protein type 11 subunit alpha (Nav1.9) (Nav1.7/Nav1.8/Nav1.9).
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