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Target intelligence / Profile preview
Sodium channel protein type II alpha subunit (SCN2A)
- Target
- SCN2A
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The sodium channel protein type II alpha subunit (SCN2A or Nav1.2) is a voltage-gated sodium channel alpha subunit predominantly expressed in the human brain. It plays a critical role in the initiation and propagation of action potentials in neurons by mediating voltage-dependent sodium ion permeability across excitable membranes. Mutations or dysfunctions of this gene/protein are associated with several neurological disorders, including epilepsy/seizure disorders, autism spectrum disorder, and infantile spasms.
- Other names
- NAC2SCN2A1SCN2A2HBSC IISodium channel protein brain II subunit alphaVoltage-gated sodium channel subunit alpha Nav1.2
02
Mechanism of action
Voltage-dependent Na+ influx; Modulation of neuronal excitability
03
Biological functions
Action potential initiationAction potential propagationNeuronal excitabilitySignal transmissionSodium ion transmembrane transport
04
Disease associations
Epilepsy/seizure disordersAutism spectrum disorderInfantile spasmsBitemporal glucose hypometabolismBipolar disorder
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