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Target intelligence / Profile preview
Sodium channel protein type IIA alpha subunit (Nav1.2)
- Target
- Nav1.2
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The sodium channel protein type IIA alpha subunit (Nav1.2) is a pore-forming component of voltage-gated sodium channels (VGSCs) essential for initiating and propagating action potentials in excitable cells. It is a major target for local anesthetics and anticonvulsants. Mutations in the SCN2A gene, which encodes Nav1.2, are associated with various neurological disorders, including epilepsy and neurodevelopmental syndromes.
- Other names
- SCN2AVoltage-gated sodium channel subunit alpha Nav1.2
02
Mechanism of action
Blockage of sodium ion flow through the channel pore.
03
Biological functions
Action potential generationSodium ion transportNeuronal excitabilityMembrane depolarization
04
Disease associations
EpilepsyNeurodevelopmental disordersCardiac arrhythmias
05
Safety considerations
Cardiac arrhythmiasNeurological side effectsDrug interactions
06
Interacting drugs
Lidocaine
3 more in the full profile.
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