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Target intelligence / Profile preview
Sodium channel protein type IX alpha subunit (Nav1.7)
- Target
- Nav1.7
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
Nav1.7 is a voltage-gated sodium channel that forms the pore-forming alpha subunit of the channel complex. It is critical for generation and conduction of action potentials, particularly in neurons involved in pain signaling (nociceptors). Mutations in SCN9A/Nav1.7 are associated with several human pain disorders, including congenital insensitivity to pain, primary erythromelalgia, and paroxysmal extreme pain disorder. It is a major target for analgesic drug development.
- Other names
- SCN9AVoltage-gated sodium channel type IX alphaPeripheral sodium channel 1PN1hNE-NaSodium voltage-gated channel alpha subunit 9
02
Mechanism of action
Sodium channel blockade
03
Biological functions
Generation and conduction of action potentialsRegulation of resting membrane potentialNociceptionOlfaction
04
Disease associations
Congenital insensitivity to painPrimary erythromelalgiaParoxysmal extreme pain disorderPain
05
Safety considerations
Potential for off-target effects on other sodium channelsCardiovascular effects
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