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Target intelligence / Profile preview
Sodium channel protein type subunit alpha (Nav alpha subunit)
- Target
- Nav alpha subunit
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The pore-forming, principal component of voltage-gated sodium channels (VGSCs), essential for action potential initiation and propagation in excitable cells. The alpha subunit alone forms a functional sodium channel that conducts Na⁺ ions in response to changes in membrane potential. Multiple isoforms exist (Nav1.1-Nav1.9), encoded by different genes (SCN1A-SCN11A), with tissue-specific expression and unique physiological roles. Mutations in SCN genes are linked to various neurological, cardiac, and pain disorders.
- Other names
- Voltage-gated sodium channel alpha subunitVGSC alpha subunit
02
Mechanism of action
Blockade of sodium channel conductance, modulation of channel gating
03
Biological functions
Action potential initiation and propagationNeuronal signalingMuscle contractionCardiac conductionSodium ion transmembrane transport
04
Disease associations
EpilepsyAutism spectrum disordersInfantile spasmsBrugada syndromeCardiac arrhythmiasPain syndromes
05
Safety considerations
Cardiac arrhythmiasNeurological side effectsDrug interactions
06
Interacting drugs
Local anesthetics
2 more in the full profile.
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