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Target intelligence / Profile preview
Sodium channel protein type V alpha subunit (NaV1.5)
- Target
- NaV1.5
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The sodium channel protein type V alpha subunit (NaV1.5) is a voltage-gated sodium channel primarily expressed in cardiac muscle. Encoded by the SCN5A gene, it mediates the fast influx of sodium ions during the depolarization phase of cardiac action potentials, crucial for impulse propagation and heart muscle contraction. Mutations in SCN5A are associated with inherited arrhythmia syndromes like Long QT syndrome type 3 and Brugada syndrome. Aberrant expression has also been linked to certain cancers.
- Other names
- SCN5AhH1Sodium channel protein cardiac muscle subunit alphaVoltage-gated sodium channel subunit alpha Nav1.5
02
Mechanism of action
Blockade of sodium ion influx through the channel pore
03
Biological functions
Cardiac muscle contractionPropagation of electrical signals in the heartRegulation of membrane potentialIon transport
04
Disease associations
Long QT syndrome type 3Brugada syndromeArrhythmiaSudden cardiac deathOral squamous cell carcinoma
05
Safety considerations
Proarrhythmic effects of some NaV1.5 blockersDrug-induced QT prolongationInteractions with other medications affecting cardiac conduction
06
Interacting drugs
Antiarrhythmic drugs (e.g., lidocaine, mexiletine)
1 more in the full profile.
07
Biomarkers
SCN5A mutations (for risk stratification in inherited arrhythmia syndromes)Expression levels in cancer cells (potential prognostic marker)
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