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Target intelligence / Profile preview
Sodium channel protein type VIII alpha subunit (Nav1.6)
- Target
- Nav1.6
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The sodium channel protein type VIII alpha subunit, also known as Nav1.6, is a voltage-gated sodium channel encoded by the SCN8A gene. It forms the ion-conducting pore of the channel and plays a critical role in generating and propagating action potentials in neurons, particularly at nodes of Ranvier. Mutations in SCN8A are associated with various neurological disorders, including epileptic encephalopathy, intellectual disability, and movement disorders. It is an active target for drug development focused on central nervous system diseases.
- Other names
- SCN8ACERIIICIATEIEE13MEDNaCh6PN4sodium voltage-gated channel alpha subunit 8BFIS5MYOCL2DEE13
02
Mechanism of action
Voltage-dependent sodium ion conductance
03
Biological functions
Action potential generationSodium ion transportNeuronal excitabilitySignal transduction
04
Disease associations
Epileptic encephalopathyIntellectual disabilityMovement disordersEpilepsyPain
05
Safety considerations
Altered neuronal excitabilityPotential for seizuresCardiac arrhythmia
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