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Target intelligence / Profile preview
Sodium channel protein type X alpha subunit (Nav1.8)
- Target
- Nav1.8
- Molecular classification
- Voltage-gated sodium channel, Ion channel
01
Overview
Nav1.8 is a tetrodotoxin-resistant (TTX-R) voltage-gated sodium channel alpha subunit encoded by the SCN10A gene. It is primarily expressed in nociceptive sensory neurons and plays a crucial role in pain signaling, particularly in inflammatory, neuropathic, and cold-induced pain. Selective Nav1.8 blockers are being developed as analgesics, offering a potential therapeutic approach for managing chronic pain conditions.
- Other names
- SCN10A
02
Mechanism of action
Inhibition of Nav1.8 sodium channels
03
Biological functions
Action potential generationAction potential propagationNociceptionPain signalingNeuronal excitability
04
Disease associations
Neuropathic painInflammatory painCold-induced painCardiac arrhythmiasMultiple sclerosis-related symptoms
05
Safety considerations
Potential for off-target effects on other voltage-gated sodium channels if selectivity is not high enough.Cardiac conduction abnormalities
06
Interacting drugs
Tetrodotoxin (TTX)
1 more in the full profile.
07
Biomarkers
SCN10A variants associated with painful neuropathy syndromes
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