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Target intelligence / Profile preview
Thiazide-Sensitive Sodium-Chloride Cotransporter (NCC)
- Target
- NCC
- Molecular classification
- Transporter, Membrane protein
01
Overview
The thiazide-sensitive sodium-chloride cotransporter (NCC), encoded by the SLC12A3 gene, is a membrane protein located in the apical membrane of distal convoluted tubule (DCT) cells. It mediates electroneutral co-transport of sodium (Na+) and chloride (Cl-) ions from the tubular fluid into the epithelial cells. NCC plays a critical role in regulating salt balance, blood pressure, and overall electrolyte homeostasis. It is the target of thiazide diuretics, widely used antihypertensive agents. Mutations in SLC12A3 cause Gitelman syndrome, a hereditary salt-wasting disorder.
- Other names
- Sodium-Chloride CotransporterSodium-Chloride SymporterSLC12A3
02
Mechanism of action
Inhibition of Na+ and Cl- reabsorption in the distal convoluted tubule
03
Biological functions
Sodium reabsorptionChloride reabsorptionSalt balance regulationBlood pressure regulationElectrolyte homeostasis
04
Disease associations
HypertensionGitelman syndrome
05
Safety considerations
Electrolyte imbalances (hypokalemia, hypomagnesemia)Hypotension
06
Interacting drugs
Thiazide diuretics
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