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Target intelligence / Profile preview
Sodium-dependent Citrate Transporter (NaCT)
- Target
- NaCT
- Molecular classification
- Solute Carrier Family 13 (SLC13), Transporter
01
Overview
Sodium-dependent citrate transporter (NaCT), encoded by the SLC13A5 gene, is a sodium-coupled symporter responsible for importing citrate into cells, primarily in the liver and brain. It plays a crucial role in regulating cytosolic citrate levels, influencing fatty acid synthesis, cholesterol biosynthesis, and energy metabolism. NaCT deficiency or mutation leads to disrupted hepatic metabolism and neurological disorders. NaCT inhibition is being explored as a therapeutic strategy for metabolic diseases.
- Other names
- mINDYmammalian IndySLC13A5
02
Mechanism of action
Inhibition of citrate uptake by competitive inhibitors.
03
Biological functions
Citrate transportRegulation of fatty acid synthesisRegulation of cholesterol biosynthesisEnergy metabolismRegulation of glycolysisRegulation of TCA cycle activity
04
Disease associations
Pediatric epilepsyNeonatal epileptic encephalopathyMetabolic disordersObesityType 2 diabetes mellitusNon-alcoholic fatty liver disease (NAFLD)CancerNeurodevelopmental disorders
05
Safety considerations
Systemic inhibition may cause neurological phenotypesSpecies-specificity of inhibitors needs consideration
06
Interacting drugs
BI01383298
2 more in the full profile.
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