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Target intelligence / Profile preview
Sodium-dependent Dopamine Transporter (DAT)
- Target
- DAT
- Molecular classification
- Transporter, Neurotransmitter:sodium symporter, SLC6 family
01
Overview
The sodium-dependent dopamine transporter (DAT/SLC6A3) is an essential regulator of dopaminergic neurotransmission through high-affinity uptake mechanisms tightly coupled with sodium gradients at neuronal membranes. It plays critical roles not only under normal physiological conditions but also as a key target for multiple neuropsychiatric medications—and its dysfunction contributes directly to several major brain diseases including ADHD, Parkinson’s disease, bipolar disorder, substance abuse syndromes among others.
- Other names
- SLC6A3DAT1DA transporterSolute carrier family 6 member 3
02
Mechanism of action
Inhibition of dopamine reuptake; Induction of reverse transport (efflux)
03
Biological functions
Dopamine uptake/transportMonoamine neurotransmitter clearanceRegulation of locomotor behavior
04
Disease associations
Attention deficit hyperactivity disorderCorneal diseaseNarcolepsyObesityParkinsonismBipolar disorderDepressionSubstance use disordersHIV-associated neurocognitive disordersParkinson’s disease
05
Interacting drugs
Cocaine
3 more in the full profile.
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