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Target intelligence / Profile preview
Sodium-dependent neutral amino acid transporter (ASCT2)
- Target
- ASCT2
- Molecular classification
- Solute Carrier Family SLC1, Transporter
01
Overview
The sodium-dependent neutral amino acid transporter, also known as system ASC or ASCT2 (SLC1A5), is a membrane protein responsible for the sodium-dependent uptake of small neutral amino acids. It plays a crucial role in cellular amino acid homeostasis and is particularly important in tissues such as the brain. It primarily transports alanine, serine, cysteine, threonine, and methionine, with glutamine as its preferred substrate. It has been implicated in cancer metabolism due to its role in glutamine uptake.
- Other names
- System ASCSLC1A5Alanine, Serine, Cysteine Transporter 2
02
Mechanism of action
Inhibition of glutamine uptake; Inhibition of alanine, serine, cysteine, threonine, and methionine transport
03
Biological functions
Amino acid transportNutrient uptakeCellular amino acid homeostasis
04
Disease associations
Cancer
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