Sodium-dependent neutral amino acid transporter B(0)AT1 (SLC6A19 (also known as B0AT1))

Sodium-dependent neutral amino acid transporter B(0)AT1 is a membrane protein encoded by the SLC6A19 gene. It mediates the sodium-dependent uptake and epithelial resorption of all neutral amino acids across the apical membrane in both kidney and intestinal epithelial cells. This function is critical for maintaining systemic levels of essential and non-essential neutral amino acids. For proper surface expression and catalytic activity, B(0)AT1 requires coexpression with collectrin (TMEM27). Mutations in this gene cause Hartnup disease, a disorder characterized by defective transport of certain amino acids leading to various clinical symptoms. The transporter has also been identified as a possible therapeutic target for metabolic diseases such as type 2 diabetes due to its central role in nutrient handling. Benztropine has been shown experimentally to act as a selective competitive inhibitor of this transporter.

Other names

SLC6A19B0AT1HNDsolute carrier family 6 member 19

Competitive inhibition of sodium-dependent uptake of neutral amino acids by blocking the transporter’s substrate binding site