Sodium-dependent neutral amino acid transporter B0AT1 (B0AT1)

Sodium-dependent neutral amino acid transporter B0AT1 (SLC6A19) is a membrane protein responsible for the sodium-coupled uptake of neutral amino acids across the apical membrane of epithelial cells in the intestine and proximal tubules of the kidney[2][3][4][8][9]. This transporter is crucial for absorption of dietary amino acids in the gut and their reabsorption in the kidney, thereby preventing excessive amino acid loss in urine. Genetic defects in SLC6A19 result in Hartnup disease, characterized by aminoaciduria and variable neuropsychiatric or dermatological symptoms. B0AT1 belongs to the solute carrier 6 family of transporters, is sodium-dependent but chloride-independent, and plays a fundamental role in systemic amino acid homeostasis[1][2][3][4][8][9].

Other names

SLC6A19Solute carrier family 6 member 19Sodium-dependent amino acid transporter system B0System B0 neutral amino acid transporterSystem B(0) neutral amino acid transporter AT1HND

Inhibitors or mutations disrupt neutral amino acid uptake across intestinal and renal epithelium