Sodium-dependent neutral amino acid transporter type 2 (SLC1A5 (also known as ASCT2))

Sodium-dependent neutral amino acid transporter type 2 (SLC1A5, also known as ASCT2) is a membrane-bound transporter protein belonging to the solute carrier family 1. It primarily facilitates the sodium-dependent transport of neutral amino acids, particularly glutamine, across the plasma membrane[1][2]. ASCT2 is bi-directional and selective, harmonizing intracellular and extracellular amino acid pools. It is notably overexpressed in various malignancies and proliferative cells, making it an attractive pharmacologic target for inhibiting tumor growth by depriving cells of glutamine[2][4]. Beyond its transport role, SLC1A5 also serves as a receptor for certain retroviruses. The transporter’s structure, expression, and regulatory mechanisms are under active investigation due to its therapeutic potential in oncology and other proliferative diseases[1][2].

Other names

ASCT2AAATSystem ASCNeutral amino acid transporter B(0)Solute carrier family 1 member 5Baboon M7 virus receptorRD114/simian type D retrovirus receptor

Inhibitors typically block the transporter’s ability to import neutral amino acids (notably L-glutamine), depriving cancer cells of nutrients and suppressing cell proliferation and survival[2].\nTargeting SLC1A5 can disrupt tumor metabolism, growth, and mTOR signaling.