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Target intelligence / Profile preview
Sodium-dependent Noradrenaline Transporter (NET)
- Target
- NET
- Molecular classification
- Transporter, Membrane protein
01
Overview
The sodium-dependent noradrenaline transporter (NET) is a membrane protein responsible for the reuptake of extracellular norepinephrine (noradrenaline) and, to a lesser extent, dopamine from the synaptic cleft back into presynaptic neurons. This process is essential for regulating neurotransmitter levels in the central and peripheral nervous systems. Dysfunction or altered expression has been linked to psychiatric disorders such as ADHD and depression; it is also implicated in cardiovascular diseases. NET is targeted by several classes of drugs, including tricyclic antidepressants and SNRIs.
- Other names
- Norepinephrine transporterNAT1NET1SLC6A5solute carrier family 6 member 2
02
Mechanism of action
Inhibition of norepinephrine and/or dopamine reuptake from the synaptic cleft.
03
Biological functions
Neurotransmitter transmembrane transporter activityRegulation of chemical synaptic transmissionDopamine uptake involved in synaptic transmissionNeuron cellular homeostasisResponse to xenobiotic stimulus
04
Disease associations
ADHDDepressionCardiovascular diseases
05
Safety considerations
Potential for cardiovascular side effectsDrug interactionsVariability in drug response
06
Interacting drugs
Tricyclic antidepressants
2 more in the full profile.
07
Biomarkers
Single-nucleotide polymorphisms in SLC6A2
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