Sodium-dependent phosphate transport protein 1 (NPT1)

Sodium-dependent phosphate transport protein 1 (NPT1), encoded by the SLC17A1 gene, is an integral membrane protein primarily expressed in the renal proximal tubules, where it is responsible for the sodium-dependent reabsorption of inorganic phosphate from urine into blood[1]. It also plays a significant role in urate transport and is involved in the regulation of uric acid levels[1]. Mutations or dysfunctions in SLC17A1 are associated with disorders such as hyperuricemia and uric acid nephrolithiasis[1]. As a member of the solute carrier (SLC) family 17, NPT1 acts as an organic anion transporter and is part of the major facilitator superfamily[5]. This transporter is considered a potential therapeutic target for diseases related to phosphate and urate metabolism[1].

Other names

Solute carrier family 17 member 1SLC17A1Sodium-dependent phosphate cotransporter 1Renal sodium-dependent phosphate transport protein 1NAPI-1Solute carrier family 17 (organic anion transporter), member 1

Inhibition of sodium-dependent phosphate reabsorption; Modulation of urate excretion in the kidney