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Sodium-dependent phosphate transporter type IIb (NaPi-IIb)
- Target
- NaPi-IIb
- Molecular classification
- Transporter, SLC34 family, Type II Sodium-dependent Phosphate Transporter
01
Overview
Sodium-dependent phosphate transporter type IIb (NaPi-IIb/SLC34A2) is a critical epithelial membrane protein responsible for electrogenic cotransport of sodium ions with inorganic phosphate—primarily facilitating dietary phosphorus uptake from the intestine but also functioning in other organs such as lung. Its activity directly impacts whole-body phosphorus balance. Mutations can cause rare diseases like pulmonary alveolar microlithiasis; overexpression on certain tumors makes it an attractive target for antibody-drug conjugate therapies under development for cancers such as ovarian carcinoma. Downregulation or dysfunction may contribute to disordered mineral metabolism seen in chronic kidney disease patients.
- Other names
- NPTIIbNaPi2bNAPI-3Bsodium-dependent phosphate transport protein 2B
02
Mechanism of action
Electrogenic cotransport of 3 Na+ : 1 HPO4(2−)
03
Biological functions
Phosphate transportIntestinal phosphate absorptionSystemic phosphate homeostasis
04
Disease associations
Pulmonary alveolar microlithiasisOvarian cancerChronic kidney disease
05
Safety considerations
Potential for off-target effects with antibody-drug conjugatesDisruption of phosphate homeostasis
06
Interacting drugs
Antibody-drug conjugates targeting NaPi2b
07
Biomarkers
NaPi-IIb cell surface localization in ovarian cancer
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