Sodium-dependent phosphate transport protein 2C (SLC34A3)

Sodium-dependent phosphate transport protein 2C is an integral membrane transporter responsible for the reabsorption of inorganic phosphate in the kidney via sodium-coupled transport. It regulates local and systemic phosphate concentrations, supporting bone health, cellular metabolism, and energy production. Dysfunction or genetic mutations in this transporter (SLC34A3 gene) cause hereditary hypophosphatemic rickets with hypercalciuria, marked by phosphate wasting, rickets, and increased vitamin D levels. The protein is a member of the SLC34 family and primarily expressed in the renal proximal tubule, mediating 2 Na+:1 phosphate ion exchange. Its activity is fundamental for maintaining balance of phosphate and overall mineral metabolism

Other names

Na(+)-dependent phosphate cotransporter 2CSodium/inorganic phosphate cotransporter IICSodium/phosphate cotransporter 2CSolute carrier family 34 member 3SLC34A3NaPi-IIcNPT2C

Drugs or small molecules targeting Sodium-dependent phosphate transport protein 2C would exert action by modulating renal phosphate reabsorption (typically by inhibiting or enhancing transporter activity)