Sodium-dependent phosphate transport protein 3 (SLC17A2)

Sodium-dependent phosphate transport protein 3 (SLC17A2) is a member of the solute carrier family 17 and functions primarily as a sodium-dependent phosphate (Na+/Pi) cotransporter and membrane potential-driven organic anion transporter[1][2][3]. SLC17A2 mediates the movement of inorganic phosphate into cells, as well as the transport of urate and various organic anions, via mechanisms dependent on sodium gradients and membrane potential[3][4]. It is widely expressed in tissues such as the kidney, liver, placenta, thyroid, lung, and brain, indicating roles in systemic phosphate and urate circulation[2]. As a polyspecific transporter, SLC17A2 may contribute to both normal renal handling of phosphate and urate and the pathogenesis of disorders such as Fanconi renotubular syndrome 2[3]. Key structural and functional features: - Categorized as a sodium/phosphate symporter in the Phosphate:Na+ Symporter (PNaS) family[4]. - Has a related paralog, SLC17A4, and is distinguished from other sodium-phosphate transporters by substrate specificity and regulation[3]. - Drugs that inhibit SLC17A2 typically act by blocking its organic anion or phosphate cotransport function[2].

Other names

NPT3Na(+)/Pi cotransporter 3sodium phosphate transporter 3sodium/phosphate cotransporter 3solute carrier family 17 member 2sodium-dependent phosphate transport protein 3

Inhibition of organic anion transport; blockade of sodium-dependent phosphate uptake[2]