Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-dependent phosphate transporter
- Molecular classification
- Transporter, SLC34 family, SLC20 family
01
Overview
Sodium-dependent phosphate transporters are membrane proteins that mediate the uptake of inorganic phosphate (Pi) into cells by coupling its transport to the movement of sodium ions (Na+). These transporters play a crucial role in maintaining phosphate homeostasis, which is essential for various physiological processes including bone mineralization, energy metabolism, and cellular signaling. The main families are SLC34 (Type II sodium-phosphate cotransporters) and SLC20 (Type III sodium-phosphate cotransporters). Key isoforms include SLC34A1 (NaPi-IIa), SLC34A2 (NaPi-IIb), SLC34A3 (NaPi-IIc), SLC20A1 (PiT1), and SLC20A2 (PiT2). Regulation occurs via Parathyroid hormone (PTH), Dietary Phosphate, Vitamin D metabolites (e.g., calcitriol), and FGF23 hormone. Mutations or dysfunctions can lead to Hypophosphatemia, Nephrolithiasis and Osteoporosis.
- Other names
- Na+-Pi cotransporterSodium/phosphate symporter
02
Mechanism of action
Inhibiting or enhancing phosphate transport across cell membranes.
03
Biological functions
Phosphate transportPhosphate homeostasisBone mineralizationEnergy metabolismCellular signaling
04
Disease associations
HypophosphatemiaNephrolithiasisOsteoporosisHypophosphatemia nephrolithiasis/osteoporosis type I syndrome
Beyond the preview
Go deeper on Sodium-dependent phosphate transporter.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-dependent phosphate transporter.