Sodium-dependent phosphate transporter 2 (SLC20A2)

Sodium-dependent phosphate transporter 2 (SLC20A2, PiT-2) is a transmembrane transporter belonging to the solute carrier family, critical for the sodium-dependent uptake of inorganic phosphate. It forms homodimers, operates primarily in the brain and bone, and is essential for normal cellular function, including energy metabolism and nucleic acid synthesis. SLC20A2 also acts as a cell surface receptor for certain retroviruses. Pathogenic mutations cause phosphate metabolism dysfunction and abnormal calcium-phosphate deposition in the brain, notably leading to diseases like primary familial brain calcification (Fahr's syndrome), and are implicated in bone quality and strength. Its dual role in transport and viral entry underscores a diverse functional and clinical significance

Other names

PiT-2SLC20A2Sodium-dependent phosphate transporter 2Gibbon ape leukemia virus receptor 2GLVR2MLVARMurine leukemia virus amphotropic receptor

For potential drugs: inhibition or modulation of phosphate transport to correct or mitigate abnormal mineralization and calcification. For retroviral entry, blockade of viral-receptor interaction.