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Target intelligence / Profile preview
Sodium-dependent phosphate transporter PiT-1
- Molecular classification
- Membrane symporter, Solute Carrier Family 20 (SLC20), Transporter
01
Overview
Sodium-dependent phosphate transporter PiT-1 (SLC20A1) is a member of the solute carrier 20 (SLC20) family of membrane proteins. It functions primarily as a sodium-phosphate symporter, transporting inorganic phosphate (Pi), specifically the monovalent form (H₂PO₄⁻), into cells. PiT-1 plays a crucial role in maintaining physiological phosphate homeostasis and is involved in vascular calcification, renal disease, and other pathologies. It is also implicated in cell proliferation and cancer biology.
- Other names
- SLC20A1Sodium-dependent phosphate transporter 1PiT‑1
02
Mechanism of action
Inhibition of PiT-1 mediated phosphate uptake
03
Biological functions
Na⁺/phosphate co-transporterMaintains cellular/systemic Pᵢ homeostasisPhosphate HomeostasisCellular metabolismSensor for extracellular phosphate levelsRegulation of cell proliferationErythroid differentiationBone metabolism
04
Disease associations
Vascular calcificationChronic Kidney Disease (CKD)Diabetes-related complicationsPodocyte InjuryRenal DiseaseCancer
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