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Sodium-dependent phosphate transporter PiT-2 (PiT-2)
- Target
- PiT-2
- Molecular classification
- Solute Carrier Family 20 (SLC20), Type III sodium-phosphate co-transporter, Transporter
01
Overview
Sodium-dependent phosphate transporter PiT-2 is a membrane protein responsible for the sodium-coupled transport of inorganic phosphate (Pi) into cells. It is encoded by the SLC20A2 gene and belongs to the solute carrier 20 (SLC20) family. PiT-2 plays a crucial role in intracellular transport of inorganic phosphate, phosphate homeostasis, and may act as a sensor mediating intracellular signaling dependent on extracellular phosphate levels. Alterations in SLC20A2/PiT-2 are associated with familial idiopathic basal ganglia calcification, chronic kidney disease & vascular calcification, and diabetic nephropathy.
- Other names
- SLC20A2GLVR-2GLVR2
02
Mechanism of action
Sodium-phosphate symporter; couples two Na+ ions per transported HxPO4(3-x), driven by extracellular Na+ gradients.
03
Biological functions
Intracellular transport of inorganic phosphatePhosphate homeostasisNucleotide biosynthesisEnergy metabolism (ATP production)Cell signalingMembrane lipid synthesisInsulin signalingViral entry receptor
04
Disease associations
Familial idiopathic basal ganglia calcificationChronic kidney diseaseVascular calcificationDiabetic nephropathy
05
Safety considerations
Altered phosphate homeostasis leading to calcificationPotential effects on insulin sensitivity
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