Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-dependent phosphate transporter protein 2B (NaPi2b)
- Target
- NaPi2b
- Molecular classification
- Transporter, SLC34 family of type II sodium-phosphate co-transporters
01
Overview
NaPi2b is a sodium-dependent phosphate transporter protein that plays a crucial role in maintaining phosphate homeostasis by mediating the active transport of inorganic phosphate into cells. It is expressed in various tissues, including the lung, small intestine, salivary glands, mammary glands, liver, and kidney. NaPi2b is significantly overexpressed in several human cancers, including ovarian, lung, thyroid, and breast cancers, making it a promising therapeutic target for antibody-drug conjugates. Inhibition of NaPi2b expression has been shown to suppress tumor growth and proliferation, and promote apoptosis.
- Other names
- NPTIIbNPT2bNaPi-3BSolute carrier family 34 member 2SLC34A2Na(+)-dependent phosphate cotransporter 2BSodium/phosphate cotransporter 2BNa(+)/Pi cotransporter 2BSLC34A22
02
Mechanism of action
Antibody-drug conjugates targeting NaPi2b to deliver cytotoxic payloads to cancer cells
03
Biological functions
Phosphate transportRegulation of phosphate homeostasisDietary phosphate absorptionRegulation of intraalveolar fluidSurfactant productionSecretion/reabsorption of phosphate
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to expression in normal tissues (lung, small intestine, salivary gland, mammary gland, liver, kidney).Toxicity associated with antibody-drug conjugates.Potential for drug resistance.
06
Interacting drugs
Upifitamab rilsodotin
2 more in the full profile.
07
Biomarkers
NaPi2b overexpression in ovarian cancerNaPi2b overexpression in lung cancerNaPi2b overexpression in thyroid cancerNaPi2b overexpression in breast cancer
Beyond the preview
Go deeper on Sodium-dependent phosphate transporter protein 2B (NaPi2b).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-dependent phosphate transporter protein 2B (NaPi2b).