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Sodium-dependent phosphate transporter type IIb (NaPi-IIb), Sodium-dependent phosphate transporter 1 (PiT-1), and Sodium-dependent phosphate transporter 2 (PiT-2) (NaPi-IIb, PiT-1, PiT-2)
- Target
- NaPi-IIb, PiT-1, PiT-2
- Molecular classification
- Transporter, Membrane protein
01
Overview
Sodium-dependent phosphate transporter type IIb (NaPi-IIb, SLC34A2) and sodium-dependent phosphate transporters 1 and 2 (PiT-1/SLC20A1, PiT-2/SLC20A2) are membrane proteins responsible for the majority of active phosphate transport in the intestine (NaPi-IIb) and for cellular phosphate uptake in multiple tissues (PiT-1 and PiT-2). They play essential roles in phosphate absorption, systemic phosphate balance, and are implicated in several hereditary and acquired metabolic and bone diseases[1][2][4]. NaPi-IIb is primarily found in the small intestine and lungs, whereas PiT-1 and PiT-2 have broad tissue distribution, serving both housekeeping and specialized regulatory functions in phosphate metabolism.
- Other names
- SLC34A2Npt2bSLC20A1PiT1SLC20A2PiT2
02
Mechanism of action
Competitive inhibition (for available sodium-phosphate transporter inhibitors)
03
Biological functions
Phosphate transport and absorptionRegulation of systemic phosphate homeostasisCellular phosphate uptake (housekeeping function)
04
Disease associations
Pulmonary alveolar microlithiasis (mutations implicated)Phosphate metabolism disordersBone diseaseCardiovascular disease
05
Safety considerations
HypophosphatemiaHyperphosphatemiaNephrocalcinosisBone mineralization defectsPulmonary alveolar microlithiasisCardiovascular health issuesRenal health issues
06
Interacting drugs
PF-06869206
1 more in the full profile.
07
Biomarkers
NaPi-IIb RNA/protein expressionPiT-1 RNA/protein expressionPiT-2 RNA/protein expressionPlasma phosphate levelsFGF23 levelsParathyroid hormone (PTH) levels
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