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Sodium-dependent phosphate transporter type III alpha chain (PiT-1)
- Target
- PiT-1
- Molecular classification
- Transporter, Solute Carrier Family 20 (SLC20), Type III Sodium-phosphate Cotransporter
01
Overview
PiT-1 (Sodium-dependent phosphate transporter type III alpha chain), encoded by the SLC20A1 gene, is a key membrane protein responsible for the high-affinity, sodium-coupled import of inorganic phosphate into cells. Beyond its transport function, PiT-1 acts as a sensor and regulator, influencing cell fate decisions in pathological conditions such as vascular calcification associated with chronic kidney disease (CKD) and diabetic nephropathy, impacting podocytes and insulin sensitivity mechanisms.
- Other names
- SLC20A1Phosphate transporter 1PiT1
02
Biological functions
Phosphate transportPhosphate homeostasisPhosphate sensingCellular signaling
03
Disease associations
Vascular calcificationChronic kidney disease (CKD)Diabetes mellitusPodocyte injuryInsulin resistanceGlomerular dysfunctionHyperphosphatemia
04
Safety considerations
Altering phosphate levels systemicallyOff-target effects due to ubiquitous expression
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