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Sodium-dependent phosphate transporter type III member 1 (PiT-1)
- Target
- PiT-1
- Molecular classification
- Transporter, Sodium-phosphate symporter
01
Overview
Sodium-dependent phosphate transporter type III member 1 (PiT-1) is a membrane protein that mediates the uptake of inorganic phosphate into cells by coupling its transport to the movement of sodium ions. It plays a crucial role in maintaining phosphate homeostasis and is implicated in vascular calcification, making it a potential therapeutic target for cardiovascular and kidney diseases.
- Other names
- SLC20A1
02
Mechanism of action
Inhibition of sodium-phosphate symport
03
Biological functions
Inorganic phosphate transportPhosphate homeostasisBone mineralizationEnergy metabolismNucleotide synthesis
04
Disease associations
Cardiovascular diseaseChronic kidney diseaseVascular calcificationHyperphosphatemia
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