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Sodium-dependent phosphate transporter type III member 2 (PiT-2)
- Target
- PiT-2
- Molecular classification
- Solute Carrier Family 20, Type III sodium-dependent phosphate symporter, Transporter
01
Overview
Sodium-dependent phosphate transporter type III member 2 (PiT-2), encoded by the SLC20A2 gene, is a sodium-phosphate symporter that plays a crucial role in maintaining cellular and systemic phosphate homeostasis. It transports inorganic phosphate across cell membranes, primarily in neurons and kidney proximal tubule cells. PiT-2 also serves as an entry receptor for some oncoretroviruses. Mutations in SLC20A2 can lead to primary familial brain calcification.
- Other names
- SLC20A2
02
Mechanism of action
Sodium-coupled import/export of inorganic monovalent phosphates
03
Biological functions
Phosphate transportRegulation of intracellular and extracellular phosphate levelsViral receptor activityMaintenance of phosphate homeostasis
04
Disease associations
Primary familial brain calcificationVascular calcificationMovement disordersPsychiatric symptoms
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