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Sodium-glucose co-transporter 1 (SGLT1)

Target: SGLT1
Molecular classification: Transporter, Membrane protein

Overview

Sodium-glucose co-transporter 1 (SGLT1) is a membrane protein responsible for the active transport of glucose and galactose into cells, primarily in the small intestine and kidney tubules. It mediates secondary active transport, using the sodium gradient to drive uptake of glucose against its concentration gradient. SGLT1 is a potential therapeutic target for diabetes mellitus.

Mechanism of action

Inhibition of intestinal glucose absorption; increased urinary glucose excretion

Biological functions

Dietary monosaccharide absorptionRenal glucose reabsorptionSecondary active transportWater absorption

Disease associations

Congenital glucose-galactose malabsorption

Safety considerations

Diarrhea due to excessive intestinal glucose absorption blockage

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