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Target intelligence / Profile preview
Sodium-glucose co-transporter 2 (SGLT2)
- Target
- SGLT2
- Molecular classification
- Transporter, Membrane protein
01
Overview
Sodium-glucose co-transporter 2 (SGLT2) is a membrane protein primarily responsible for the reabsorption of glucose and sodium from the glomerular filtrate in the kidneys. It is the target of SGLT2 inhibitors, a class of drugs used to manage type 2 diabetes mellitus by reducing blood sugar levels independently of insulin action.
- Other names
- SLC5A2Solute carrier family 5 member 2
02
Mechanism of action
Inhibition of SGLT2 reduces glucose reabsorption in the kidneys, leading to increased urinary glucose excretion and lowered blood sugar levels.
03
Biological functions
Glucose reabsorptionSodium reabsorptionSecondary active transport
04
Disease associations
Type 2 diabetes mellitusDiabetic nephropathy
05
Safety considerations
Hypoglycemia (less common than with other antidiabetic agents)DiuresisFluid/electrolyte imbalanceMild metabolic acidosis
06
Interacting drugs
SGLT2 inhibitors
1 more in the full profile.
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