Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-Glucose Cotransporter 2 (SGLT2)
- Target
- SGLT2
- Molecular classification
- Sodium-glucose cotransporters, Transporter
01
Overview
Sodium-glucose cotransporter 2 (SGLT2), encoded by *SLC5A2*, is a high-capacity but low-affinity symporter responsible for most renal reabsorption of filtered plasma glucose. It plays an essential role in energy conservation but also contributes pathologically to hyperglycemia and kidney damage when overactive. Pharmacologic inhibition with selective agents has revolutionized management strategies for type 2 diabetes mellitus due to their combined metabolic, cardiovascular, and renoprotective benefits.
- Other names
- SLC5A2solute carrier family 5 member 2
02
Mechanism of action
Selective inhibition of renal SGLT2 activity, promoting glycosuria and natriuresis.
03
Biological functions
Glucose transportSodium transportRegulation of blood glucose homeostasisReabsorption of glucose
04
Disease associations
Diabetes mellitusDiabetic kidney diseaseCardiovascular diseaseHyperglycemia
05
Safety considerations
Hypoglycemia (when used with other antidiabetic agents)Genital mycotic infectionsUrinary tract infectionsDehydrationDiabetic ketoacidosis (rare)Amputation risk (canagliflozin - signal is not consistent for other drugs)Bone fractures (signal has been reported in some studies)Fournier's gangrene
06
Interacting drugs
Empagliflozin
4 more in the full profile.
07
Biomarkers
Blood glucose levelsHbA1cUrinary glucose excretioneGFR (estimated glomerular filtration rate)Albuminuria
Beyond the preview
Go deeper on Sodium-Glucose Cotransporter 2 (SGLT2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-Glucose Cotransporter 2 (SGLT2).