Target intelligence / Profile preview

Sodium-glucose cotransporter protein 2 (SGLT2)

Target: SGLT2
Molecular classification: Transporter, Sodium/glucose cotransporter, Solute carrier family 5

Overview

The sodium-glucose cotransporter protein 2 (SGLT2) is a membrane protein primarily responsible for the reabsorption of glucose in the kidney. It is an electrogenic symporter that actively transports D-glucose across cell membranes by coupling its movement with sodium ions. Inhibitors of SGLT2 are used as antidiabetic agents, and emerging evidence suggests potential roles for these inhibitors in cancer therapy.

Other names: SLC5A2solute carrier family 5 member 2

Mechanism of action

Inhibition of renal glucose reabsorption by blocking SGLT2 in proximal tubules, leading to increased urinary glucose excretion and reduced blood sugar levels.

Biological functions

Glucose transportSodium-dependent glucose transportRenal glucose reabsorption

Disease associations

DiabetesCancer

Interacting drugs

Canagliflozin

1 more in the full profile.

Beyond the preview

Go deeper on Sodium-glucose cotransporter protein 2 (SGLT2).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Sodium-glucose cotransporter protein 2 (SGLT2).

Explore the full profile