Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-glucose transporter 2 (SGLT2)
- Target
- SGLT2
- Molecular classification
- Membrane protein, Transporter, Sodium-dependent glucose cotransporter, Solute carrier
01
Overview
SGLT2 is a sodium-dependent glucose transport protein primarily responsible for the reabsorption of filtered glucose in the kidney. It is located in the early proximal tubule of the nephron and reabsorbs about 80–90% of filtered glucose from urine back into blood. Inhibition of SGLT2 leads to increased urinary excretion of glucose, lowering blood sugar levels, and is used for treating type 2 diabetes mellitus. Clinical trials have also demonstrated cardiovascular and renal protective effects independent of glycemic control.
- Other names
- Solute carrier family 5 member 2Sodium/glucose cotransporter type IISLC5A2
02
Mechanism of action
Inhibition of SGLT2, leading to increased urinary glucose excretion and reduced blood glucose levels.
03
Biological functions
Glucose transportSodium transportRenal glucose reabsorptionBlood glucose homeostasis
04
Disease associations
Type 2 diabetes mellitusChronic kidney diseaseHeart failure
05
Safety considerations
Genital mycotic infectionsUrinary tract infectionsDehydrationHypotensionDiabetic ketoacidosis (rare)Lower limb amputation (observed with some SGLT2 inhibitors)
06
Interacting drugs
Dapagliflozin
4 more in the full profile.
07
Biomarkers
Blood glucose levelsHbA1cUrinary glucose excretion
Beyond the preview
Go deeper on Sodium-glucose transporter 2 (SGLT2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-glucose transporter 2 (SGLT2).