Sodium hyaluronate–polyethylene glycol polymer–polymer complex (HA-PEG complex)

Sodium hyaluronate–polyethylene glycol (HA-PEG) polymer–polymer complex is a synthetic biomaterial system primarily utilized in advanced ophthalmic lubricants and viscosupplements. This complex leverages the high water-retention capacity of sodium hyaluronate, a natural glycosaminoglycan, and the mucoadhesive and stabilizing properties of polyethylene glycol (PEG) [Benelli et al., 2021]. In clinical applications, particularly for dry eye syndrome, the interaction between these two polymers creates a protective, hydrating shield that adheres to the ocular surface more effectively than either component alone [Rolando et al., 2021]. This dual polymer system enhances tear film stability, reduces evaporation, and provides a mechanical barrier that supports the healing of the corneal epithelium. While sodium hyaluronate can biologically interact with receptors such as CD44, the therapeutic efficacy of the HA-PEG complex is predominantly attributed to its physical-chemical properties, including its viscoelasticity and ability to form a lubricating matrix [Labetoulle et al., 2022]. Consequently, it is classified as a medical device component or an active lubricant rather than a traditional pharmacological target.

Other names

HA-PEG complexHyaluronan-polyethylene glycol conjugateSodium hyaluronate-PEG dual polymer systemPEGylated hyaluronan

The complex functions as a physical lubricant and humectant; polyethylene glycol (PEG) facilitates the anchoring and stabilization of sodium hyaluronate (HA) on biological surfaces, creating a viscoelastic matrix that stabilizes the tear film and protects the underlying epithelium from friction and desiccation [Alcon, 2020; Benelli et al., 2021].