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Target intelligence / Profile preview
Sodium Iodide Symporter (NIS)
- Target
- NIS
- Molecular classification
- Sodium/solute symporter family (SSF), Solute carrier family 5 (SLC5)
01
Overview
The sodium iodide symporter (NIS) is an intrinsic plasma membrane glycoprotein that actively mediates the transport of iodide ions into cells. It plays a critical role in concentrating iodine for thyroid hormone synthesis and has been widely adopted as an imaging reporter gene for non-invasive tracking of gene expression and cell trafficking. NIS also enables targeted radioiodine therapy by concentrating therapeutic doses of beta-emitting isotopes in target tissues.
- Other names
- SLC5A5Sodium/iodide cotransporter
02
Mechanism of action
Co-transports two sodium ions (Na+) along with one iodide ion (I-) into the cytoplasm, driven by the electrochemical sodium gradient maintained by the Na+/K+-ATPase pump.
03
Biological functions
Iodide transportThyroid hormone synthesisRadiotracer uptake
04
Disease associations
Thyroid disordersCancer (as a therapeutic target and imaging reporter)
05
Safety considerations
Off-target effects in tissues with endogenous NIS expression (e.g., salivary glands, gastric mucosa)Potential for immune response (minimized by species-specific constructs)
06
Interacting drugs
Perchlorate
5 more in the full profile.
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