Sodium monofluorophosphate (SMFP)

Sodium monofluorophosphate is an **inorganic compound** with the formula Na₂PO₃F, appearing as a white, odorless, water-soluble powder[1][2][6]. It is widely used in toothpaste as a fluoride source for preventing dental caries, owing to its ability to release fluoride ions on hydrolysis[1][5][8]. Compared to sodium fluoride, it produces less aftertaste and is less acutely toxic[1]. In some studies, it also acts as an **enzyme inhibitor** in vitro, but it is **not considered a drug target** (receptor, enzyme, transporter) for therapeutic intervention[3]. Industrially, it is produced by reacting sodium fluoride with sodium metaphosphate[1]. Used mainly as an additive in dental products, it is also researched for possible applications in osteoporosis and as an agent to reduce lead dissolution in drinking water[1]. It is **not a molecular target in the sense of biology or pharmacology** (such as a receptor or enzyme modulated by drugs), but rather an active ingredient providing fluoride for dental health.\n\n--- \n**Key interpretation:**\nSodium monofluorophosphate is not a therapeutic protein, receptor, enzyme, or drug target, but a small molecule fluoride salt directly used as an **active ingredient** (not a drug target to be modulated). Querying as a "target" is technically incorrect; structured information is presented accordingly.

Other names

Disodium monofluorophosphateSodium fluorophosphateDisodium monofluorophosphate hydrateSodium phosphorofluoridateSODIUM FLUOROPHOSPHATEPhosphorofluoridic acid, disodium saltSodium fluoride phosphateNSC-248

Provides fluoride ions, which:\n- Incorporate into tooth enamel to enhance its resistance to acid attack from bacteria, preventing demineralization and dental caries\n- At higher concentrations, can inhibit certain enzymes (pyruvate kinase, alkaline phosphatase) in vitro