Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sodium-Potassium Adenosine Triphosphatase (Na+/K+ ATPase)
- Target
- Na+/K+ ATPase
- Molecular classification
- P-type ATPase, Enzyme, Transporter
01
Overview
The Sodium-Potassium ATPase (Na+/K+ ATPase) is a transmembrane protein responsible for maintaining electrochemical gradients by actively transporting three sodium ions out of the cell and two potassium ions into the cell for each ATP molecule hydrolyzed. It is crucial for maintaining resting membrane potential, regulating cell volume, and enabling secondary active transport processes. It is a therapeutic target for cardiac glycosides used in treating congestive heart failure and arrhythmias.
- Other names
- Sodium-potassium pumpNKA
02
Mechanism of action
Inhibition of Na+/K+ ATPase activity, leading to increased intracellular calcium.
03
Biological functions
Maintains ion gradientsMaintains resting membrane potentialRegulation of cellular volumeGeneration and propagation of action potentialsSecondary active transportElectrochemical gradient maintenance
04
Disease associations
Congestive heart failureArrhythmias
05
Safety considerations
Cardiac glycoside toxicityArrhythmias due to excessive inhibition
06
Interacting drugs
Digoxin
1 more in the full profile.
Beyond the preview
Go deeper on Sodium-Potassium Adenosine Triphosphatase (Na+/K+ ATPase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sodium-Potassium Adenosine Triphosphatase (Na+/K+ ATPase).