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Target intelligence / Profile preview
Sodium-Potassium-Chloride Cotransporter 1 (NKCC1)
- Target
- NKCC1
- Molecular classification
- Cation-chloride cotransporter, Transporter
01
Overview
NKCC1 is a membrane transport protein that mediates the secondary active, electroneutral co-transport of sodium (Na⁺), potassium (K⁺), and chloride (Cl⁻) ions into cells. It plays essential roles in maintaining cell volume, ion homeostasis, fluid secretion, neuronal excitability, and cell migration. Aberrant expression or function has been linked to neurological disorders and certain cancers. Loop diuretics inhibit NKCC1.
- Other names
- SLC12A2
02
Mechanism of action
Inhibition of Na+, K+, Cl- co-transport
03
Biological functions
Ion transportCell volume regulationChloride homeostasisFluid secretionNeuronal signaling modulation
04
Disease associations
EpilepsyNeurodevelopmental disordersCancerMetastasis
05
Interacting drugs
Bumetanide
2 more in the full profile.
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