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Target intelligence / Profile preview
Sodium-Potassium-Chloride Symporter (NKCC)
- Target
- NKCC
- Molecular classification
- Transporter, Membrane Transport Protein, SLC12 family
01
Overview
The sodium-potassium-chloride symporter (NKCC) is a membrane transport protein that facilitates the coupled movement of sodium (Na⁺), potassium (K⁺), and chloride (Cl⁻) ions across cellular membranes. It plays a critical role in ion homeostasis, cell volume regulation, and neuronal excitability. There are two main isoforms: NKCC1 (ubiquitous) and NKCC2 (kidney-specific). Inhibitors like bumetanide and furosemide are used as diuretics.
- Other names
- Na-K-Cl cotransporterSLC12A1SLC12A2
02
Mechanism of action
Inhibition of Na+, K+, and Cl- translocation
03
Biological functions
Ion transportCell volume regulationRegulation of neuronal excitabilitySodium reabsorptionPotassium reabsorptionChloride reabsorption
04
Disease associations
HypertensionEdemaHeart failureKidney diseaseLiver diseaseBartter syndrome
05
Safety considerations
Electrolyte imbalanceHypokalemiaHypotension
06
Interacting drugs
Bumetanide
1 more in the full profile.
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