Target intelligence / Profile preview

Sodium-Potassium-Exchanging ATPase (Na+/K+-ATPase)

Target: Na+/K+-ATPase
Molecular classification: Enzyme, Transporter, P-type ATPase, Active cation transport protein

Overview

The Sodium-Potassium-Exchanging ATPase (Na+/K+-ATPase) is a transmembrane enzyme responsible for maintaining the electrochemical gradient across the cell membrane by actively transporting sodium ions out of the cell and potassium ions into the cell. This process is crucial for various cellular functions, including maintaining resting potential, regulating cell volume, signal transduction, and potassium homeostasis. Dysregulation of this pump can lead to various pathological conditions, particularly those related to electrolyte imbalances and cardiac function.

Other names: Na,K-activated ATPaseSodium pumpSodium/potassium-transporting ATPaseNa+/K+-Transporting ATPaseNa+-K+-Exchanging ATPasePotassium PumpSodium-Potassium Pump

Mechanism of action

Inhibition of Na+/K+-ATPase activity, leading to increased intracellular sodium and calcium levels in cardiac cells.

Biological functions

Maintenance of resting potentialCellular transportVolume regulationSignal transductionPotassium homeostasis

Disease associations

Electrolyte imbalanceCardiac dysfunctionHypertensionKidney disease

Safety considerations

Cardiac arrhythmiasElectrolyte imbalances (hypokalemia, hyperkalemia)Drug interactions (e.g., with diuretics)Toxicity in overdose

Interacting drugs

Cardiac glycosides (e.g., Digoxin, Ouabain)

2 more in the full profile.

Biomarkers

Plasma potassium levelsIntracellular sodium and potassium concentrations

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